层状双氢氧化物在生物工程应用中的研究进展

Progress in the application of layered double hydroxide in bioengineering

背景:层状双氢氧化物是一种具有良好的生物相容性和降解性的无机纳米材料,目前已有多种药物成功与其形成插层复合体,并且取得了预期的结果。目的:综述层状双氢氧化物在生物工程领域的研究与应用。方法:通过计算机检索2003/2010的文献为主,学校图书馆检索为辅。中文检索词为"纳米技术,药物载体,层状双氢氧化物,基因,基因治疗,生物传感器,靶向给药",英文检索词为"nanotechnology,drug carrier,layered double hydroxide,gene,gene therapy,biosensor,targeting drug delivery"。纳入与层状双氢氧化物应用于生物工程领域相关的文献,例如作为药物载体、基因载体以及在生物传感器等方面的应用。排除关于层状双氢氧化物物理化学性质的研究文献。结果与结论:化学性质不稳定、毒副作用大的药物(包括基因)与层状双氢氧化物的插层复合体不仅能够控释,还能提高药物的稳定性。因此,层状双氢氧化物是一类极具有发展潜力的"绿色"载体材料。但是,目前关于层状双氢氧化物在生物工程中的研究应用仅限于实验室阶段,研究人员需为其应用于临床付出更大的努力。

BACKGROUND：Layered double hydroxide is an inorganic nano-material which has the properties of good biocompatibility and biodegradability.At present,many drugs and layered double hydroxide successfully form intercalation compound and obtain expected results.OBJECTIVE：To review research progress and application of layered double hydroxide in bioengineering field.METHODS：A computer search was mainly performed among articles published from 2003 to 2010 with the Chinese and English Keywords of ＂nanotechnology,drug carrier,layered double hydroxide,gene,gene therapy,biosensor,targeting drug delivery＂,and a library search was carried out as an assist.Researches about application of layered double hydroxide as drug（gene）carrierand biosensor in bioengineering were included.Researches on little related to theme and physicochemical properties about layered double hydroxide were excluded.RESULTS AND CONCLUSION：Research shows that intercalation compound not only controls release,but also improves stability for drugs（genes）with toxic and side-effect,and instable chemical property.So,layered double hydroxide is a ＂green＂ carrier material with greatly development potential.But,research on layered double hydroxide in bioengineering is confined to laboratory,and researchers must make hard work for clinical application.