生物羊膜与新鲜羊膜移植治疗早期眼烧伤的比较

Efficacy comparison of fresh amnion and biological amnion transplantation for the treatment of early eyeburn injuries

背景:羊膜移植目前已普遍应用于眼表重建,给早期眼烧伤患者的治疗提供了新的手段。但是羊膜的选择目前还没有统一标准,临床效果的报道也有部分差异。目的:新鲜羊膜与生物羊膜移植治疗早期眼烧伤的疗效比较。方法:收集66例(66眼)早期眼烧伤患者,随机分为新鲜羊膜组和生物羊膜组,每组33例,分别采用新鲜羊膜移植和生物羊膜移植治疗。术后随访3个月,观察并比较两组视力、植片成活、并发症发生情况。结果与结论:两组术后视力较术前均有明显提高,差异有显著性意义(P<0.05);新鲜羊膜组和生物羊膜组分别有2例和3例出现羊膜早溶和脱落,经二次羊膜移植后均获成功。两组角膜白斑、角膜斑翳和角膜新生血管等并发症发生情况比较差异无显著性意义(P>0.05)。结果表明新鲜羊膜与生物羊膜均可有效治疗早期眼表烧伤,重建眼表,二者疗效比较无显著性差异。

BACKGROUND：Amniotic membrane transplantation has been commonly used in ocular surface reconstruction,it provides a new means for the treatment of early chemical injuries in eyes.But the specific choice of amniotic membrane has not yet standardized,its clinical results reported have some differences.OBJECTIVE：To compare the clinical efficacy of fresh amnion and biological amnion transplantation for the treatment of early eyeburn injuries.METHODS：A total of 66 patients（66 eyes）with early burn injuries were randomly divided into fresh amnion group and biological amnion group,with 33 cases in each group,they received fresh amnion transplantation and biological amnion transplantation respectively.All patients were followed up for 3 months after surgery,and the visual acuity,graft survival,complications were observed and compared.RESULTS AND CONCLUSION：The postoperative visual acuity of both groups improved significantly（P 0.05）;there were 2 cases and 3 cases of fresh amnion group and biological amnion group respectively occurred early dissolution and loss of amnion,and they were cured after the second transplantation.The incidence of complications such as keratoleukoma,corneal macula and corneal neovascularization had no significant difference between the two groups（P 0.05）.Both fresh amnion and biological amnion transplantation can be effective for the treatment of early ocular injuries and ocular surface reconstruction,the efficacy has no significant difference between the two methods.