内皮祖细胞信号通路调控

Regulation of Endothelial Progenitor Cell Signaling Pathway

血管内皮受到损伤后,骨髓来源的内皮祖细胞(endothelial progenitor cells,EPC)能够被动员到外周循环血液中,归巢到缺血区域或者血管损伤部位,诱导内皮细胞增殖、迁移或者自己分化为功能性内皮细胞,促进受损血管的再内皮化。因此其有望成为治疗心血管疾病的一种新的工具。然而,调控内皮祖细胞增殖、迁移、分化等生物学特性的信号通路的研究还有待深入,它既是该领域的难点,也是热点,文章就调控内皮祖细胞信号通路的研究做一综述。

After the injury of vascular endothelial,bone marrow-derived endothelial progenitor cell can be mobilized into the peripheral circulation,home to ischemic areas or sites of vascular damage,inducing endothelial cell proliferation,migration or differentiating into functional mature endothelial cell to promote the reendothelization of the damaged vessels.So it may become a new tool for treatment of cardiovascular disease.However,the signaling pathway that regulates endothelial progenitor cell proliferation,migration,differentiation and other biological characteristics needs to be thoroughly researched,which is not only difficult,but also hot in this area.This review will focus on the research regulation of endothelial progenitor cell signaling pathway.