人工肝生物反应器优化设计的仿真研究进展

The computational simulation development of bioreactor design optimization in bioartificial liver system

肝衰竭是一种病死率可高达80%的严重疾病。过去的几十年中,研究者们已经研发了多种可提供肝衰竭病人暂时肝功能支持的人工肝系统(BAL)。生物反应器是生物人工肝的核心部件,其中有着许多复杂的流体动力学问题。近年来,随着计算机技术的快速发展,基于计算机的流体动力学仿真被用于生物人工肝研究并取得了令人瞩目的成绩。仿真研究为生物反应器的进一步优化设计提供了条件。本文就计算机仿真在生物反应器优化设计中的关键问题进行了详细综述。

Liver failure is a serious disease of which mortality rate is up to 80%.During the past decades,several attempts have been made to develop bioartificial liver systems（BAL） to provide temporary hepatic support to patients with liver failure.The bio-reactor is the core of the bio-artificial liver system,which exists within the complex fluid dynamics problems.In recent years,with the rapid development of computer technology,computer-based simulation of fluid dynamics on the bio-artificial liver has been developed rapidly and achieved gratifying achievements,which provide a good condition to further optimize the bio-artificial liver reactor.In this article,important aspects of the application of computational simulation technology in bioreactor design are summarized and an overview of the critical issues in the development of bioartificial liver devices is discussed.