摘要
重组人干扰素(Recombinant human interferon,rhuIFN)是一类抗病毒、抗肿瘤和多发性硬化调节免疫的重要生物制品。自1957年发现干扰素以来,人们不断采用新技术对干扰素分子结构进行改造,先后研发了原型干扰素、保守干扰素、聚乙二醇修饰干扰素等几十个品种,目前已批准十余个一类新药干扰素上市。本文在回顾干扰素药物历史的基础上,对化学修饰改型干扰素、融合干扰素、杂合干扰素等的研究进展作一综述。
Recombinant human interferon is one of the curial biologics with immune regulatory effect,which is widely used for the treatment of virus infection,tumors and multiple sclerosis in clinic.Since interferon was discovered in 1957,its molecular structure have been modified successively by novel technique,based on which several tens of products including original type,consensus and pegylated interferon have been developed.At present,more than ten kinds of commercial interferon as new drugs class Ⅰ have been licensed.Based on the review of history of interferon,the progress in research on recombinant human interferon,such as chemically modified interferon,fussed interferon and hybrid interferon,are described in this paper.
出处
《中国生物制品学杂志》
CAS
CSCD
2010年第12期1384-1388,共5页
Chinese Journal of Biologicals
基金
国家基础研究计划项目(2007CB714301)
天津市自然科学基金项目(06YFJMC07300)
关键词
重组人干扰素
干扰素Α
化学修饰改型干扰素
融合干扰素
杂合干扰素
Recombinant human interferon
Interferon α
Chemically modified interferon
Fussed interferon
Hybrid interferon
