早孕因子的研究进展

Progress in Research on Early Pregnancy Factor

早孕因子(Early pregnancy factor,EPF)是一种具有免疫抑制和生长因子特性的分泌性蛋白质,在受精后的孕血清及某些恶性肿瘤患者血清中均能检测到。EPF与伴侣素10(Chaperonin 10,Cpn10)是同源的。EPF首先通过玫瑰花结抑制试验在哺乳动物的孕血清中被发现。EPF单克隆抗体在妊娠诊断、肿瘤诊断和治疗等方面均有广阔的应用潜力。本文就EPF的来源、化学结构和生化特性、分离纯化及检测、作用及应用等研究进展作一综述。

Early pregnancy factor（EPF）is a secreted protein with properties of immunosuppressive and growth factor,which is detected in the maternal serum after fertilization and also in the serum of some patients with malignant tumors.As a homologue of Cpn10,EPF was firstly discovered in the seraa of pregnant mammals by rosette inhibition test.The monoclonal antibodies against EPF has potential applications in the diagnosis of pregnancy as well as the diagnosis and therapy of cancer.This paper reviews the progress in research on EPF,including source,chemical structure,biochemical property,separation,purification,characterization and application.