炎症因子及脂质代谢在阿尔茨海默病和血管性痴呆中的临床意义

Clinical study of inflammatory factor and lipid metabolism on Alzheimer′s disease and vascular dementia patients

目的探讨阿尔茨海默病(AD)和血管性痴呆(VD)患者血浆中C反应蛋白(CRP)、白介素-6(IL-6)和脂质代谢异常的临床意义。方法分组测定AD30例,VD32例和正常对照31例血浆中CRP、IL-6、总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白(LDL)的水平。结果 AD和VD患者CRP和IL-6水平显著升高,且VD患者较AD患者升高更为明显;AD和VD患者血浆中TC、TG和LDL水平均较对照组明显升高,但两类患者间无显著性差异。结论炎症反应和血脂异常参与了认知功能的损害,通过对炎症因子和脂质代谢的检测有助于痴呆患者的早期诊断和治疗。

Objective To detect the clinical significances of C-reactive protein（CRP）,interleukin-6（IL-6） and dyslipidemia in Alzheimer′s disease（AD） and vascular dementia（VD） patients.Methods CRP,IL-6,cholesterol（TC）,triglyceride（TG） and low density lipoprotein（LDL） of 30 AD,32 VD patients and 31 normal people were detected.Results The CRP and IL-6 levels of both AD and VD patients increased markedly,but that of the VD patients increased more obviously compared with that of the AD patients;The TG,TC and LDL levels in AD and VD patients were also increased obviously,but there was no significant difference between them.Conclusions Both the inflammatory reaction and dyslipidemia are involved in the impairment of the cognitive ability,and it is very helpful for the early diagnosis and treat of dementia patients to detect the inflammatory factor and lipid metabolism.