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五倍子酸诱导肝癌SMMC-7721细胞凋亡 被引量：5

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摘要 目的探讨五倍子酸对人肝癌SMMC-7721细胞增殖和凋亡的影响。方法采用MTT法检测五倍子酸对SMMC-7721细胞的增殖抑制作用,瑞士-吉姆萨染色观察细胞形态变化,流式细胞仪检测细胞凋亡百分率。结果五倍子酸能抑制SMMC-7721细胞的增殖,其作用呈明显剂量依赖性。五倍子酸可诱导SMMC-7721细胞凋亡,与对照组比较差异有统计学意义。结论五倍子酸可抑制SMMC-7721细胞的增殖,并诱导其凋亡。
作者 赵洪昌
机构地区 长春市急救中心
出处 《中国老年学杂志》 CAS CSCD 北大核心 2010年第24期3728-3729,共2页 Chinese Journal of Gerontology
关键词 五倍子酸 SMMC-7721细胞:凋亡
分类号 R739.9 [医药卫生—肿瘤]
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参考文献10

  • 1范培红,娄红祥.葡萄籽多酚的分离鉴定及其对细胞DNA氧化损伤的防护作用[J].药学学报,2004,39(11):869-875. 被引量：19
  • 2Sun J,Chu YF,Wu X,et al.Antioxidant and antiproliferative activities of common fruits[J].Agric Food Chem,2002;50(25):7449-54.
  • 3Locatelli C,Rosso R,Maria C,et al.Ester derivatives of gallic acid with potential toxicity toward L1210 leukemia cells[J].Bioorg Med Chem,2008;16(1):3791-9.
  • 4Yang DJ,Hwang LS,Lin JT,et al.Effects of different steeping methods and storage on caffeine,catechins and gallic acid in bag tea infusions[J].J Chromatoga,2007;1156(1-2):312-20.
  • 5Yang HL,Chang WH,Chia YC,et al.Toona sinensis extracts induces apoptosis via reactive oxygen species in human premyelocytic leukemia cells[J].Food Chem Toxicol,2006;44(12):1978-88.
  • 6Mrozek A,Petrowsky H,Sturm I,el al.Conbined p53/Bax mutation results in extremely poor prognosis in gastric carcinoma with low microsatellite instability[J].Cell Death Differ,2003;10(4):461-7.
  • 7金伟,马力.染料木黄酮对顺铂诱导肝癌SMMC-7721细胞凋亡的增敏作用[J].第四军医大学学报,2005,26(8):761-763. 被引量：12
  • 8Abrahamsen JF,Bakken AM,Bruserud O,et al.Flow cytometric measurement of apoptosis and necrosis in cryopreserved PBPC concentrates from patientswith malignant diseases[J].Bone Marrow Transplant,2002;29(2):165-71.
  • 9Zwick E,Bange J,ULLrich A,et al.Receptor tyrosine kinase as targets for anticancer drugs[J].Trends Mol Med,2002;8(1):17-22.
  • 10刘伍梅,汪铭书,程安春.细胞凋亡检测技术的研究进展[J].中国兽医科技,2004,34(11):45-49. 被引量：14

二级参考文献41

  • 1[1]Majno G, Joris I. Apoptosis, Oncosis and necrosis: an overview of cell death [J]. Am J Pathol,1995,146(1): 3-15.
  • 2[2]Kerr J F R, Wyllie A H, Currie A R. Apoptosis: a basic phenomenon with wider-anging implications in tissue kinetics [J]. Br J Cancer,1972,26:239.
  • 3[3]Duvall E, Wyllie A H. Death and the cell [J]. Immunol Today,1986,7:115-119.
  • 4[4]Wijsman J H, Jonker R R, Keijzer R, et al. A new method to detect apoptosis in paraffin sections: in situ end-labelling of fragmented DNA [J]. J Histochem Cytochem,1993,41:7-12.
  • 5[5]Gerschenson L E, Rotello R J. Apoptosis: a different type of cell death [J]. FASEB J,1992,6:2450-2455.
  • 6[6]Uchiyama Y. Apoptosis:the history and trends of its studies [J]. Arch Histol Cytol,1995,58:127-137.
  • 7[7]Payne C M, Cromey D W. An image analysis workstation designed for multiple users: application of quantitative digital imaging techiniques to electron microscopy [J]. Ultrastruct Pathol,1992,16:147-154.
  • 8[10]Wyllie A H. Apoptosis and the regulation of cell numbers in normol and neoplastic tissues: an overview [J]. Canc Metastasis Rev,1992,11(2):95-103.
  • 9[11]Bonfoco E, Krainc D, Ankarcrona M, et al. Apoptosis and necrosis: two distinct events induced ,respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures [J]. Proc Natl Acad Sci USA,1995,92(16):7162-7166.
  • 10[13]Fehsel K, Krncke K D, Kolb H, et al. In situ nick-translation detects focal apoptosis in thymuses of glucocorticoid and lipopolysaceharide-treated mice [J]. J Histochem Cytochem,1994,42:613-619.

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中国老年学杂志
2010年 第24期

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