血管紧张素转化酶抑制剂对冠心病心力衰竭患者新发心房颤动的预防作用

Prevention of new occurred atrial fibrillation in coronary heart disease patients with heart failure by angiotensin converting enzyme inhibitors

目的:探讨血管紧张素转化酶抑制剂(ACEI)对冠心病心力衰竭患者新发心房颤动(房颤)的预防作用。方法:入选住院治疗的冠心病心力衰竭Ⅱ～Ⅳ级患者为研究对象,并对其进行随访,计算新发房颤发生率,采用单因素和多因素COX回归分析ACEI与房颤发生率的关系。结果:入选的111例患者中有21例患者发生房颤,其中ACEI组6例(6/57例,10.5%),对照组15例(15/54例,27.8%)(P<0.05),ACEI组房颤发生率明显低于对照组。通过多因素COX回归分析示ACEI是降低房颤发生的最强影响因子(P<0.01)。结论:ACEI能显著降低冠心病心力衰竭患者房颤的发生率。

Objective：To evaluate the effect of angiotensin converting enzyme inhibitors（ACEI）on prevention the development of atrial fibrillation（Af）in coronary heart disease patients with heart failure.Method：One hundred and eleven patients with heart failure in the Second Hospital of Tianjin Medical University were enrolled. Tthe incidence rates of Af were measured in our following-up.Single factor analysis and multivariate Cox model were applied to analyze sis the association of between ACEI and the incidence of Af were calculated by using SPSS17.0 software.Result：Twenty-one cases of the 111patients developed Af during follow-up,6cases（10.5%） in the ACEI group and 15 cases（27.8%）in the control group（P=0.020）,the incidence of Af in the ACEI group was significantly less than the control group.By Cox multivariate analysis,ACEI was the most powerful predictor for risk reduction of Af（P〈0.01）.Conclusion：ACEI reduce the incidence of Af in coronary heart disease patients with heart failure.