Notch的结构、功能和相关信号通路

Structure,Function and Related Signaling Pathway of Notch

Notch是广泛存在于细胞表面介导细胞间信号传递的一类高度保守的受体蛋白。Notch信号通路是通过细胞间相互作用来调节生物体生长发育的一个十分保守的信号通路。Notch信号通路在脊椎动物和无脊椎动物的发育过程中,对细胞命运的决定、神经系统的发育、器官的形成及体节的发生都有重要的作用。特别是在免疫系统和肿瘤发生中也起着极为重要的作用。目前,Notch信号已经成为发育生物学、细胞生物学、免疫学及血液学等多个领域的研究热点之一。本文就Notch信号通路的组成、调节作用机制及该通路与个体发育之间的联系作一综述。

Notch is a highly conserved cell surface receptor that mediates a wide variety of cellular interactions.Notch signaling pathway is also conserved during the evolution of the interaction between cells to regulate the biological development.The Notch signaling pathway functions in the development processes between vertebrate and invertebrates,including cell fate decision,nervous system development and the formation of organ and somites.It also plays an extremely important role in immune system and tumorigenesis.At present,Notch signaling pathway has become a hotspot issue in the fields of developmental biology,cell biology,immunology and hematology.In this paper,the structure,functions and related signaling pathway of Notch were reviewed.