潘氏细胞及其防御素的研究进展

Progress in Paneth Cell α-defensin

潘氏细胞防御素(Paneth cell defensin,PCD)在维持动物消化道内稳态、参与消化道固有免疫方面发挥重要作用,潘氏细胞的变化与肠道功能异常有密切关系。研究发现潘氏细胞α-防御素表达紊乱是炎症性肠病的关键发病因素之一。本文综述潘氏细胞的分布和形态、生物学特点、潘氏细胞防御素的生物合成过程及其功能。

Paneth cellα-defensin plays a pivotal role in maintaining intestinal homeostasis and innate immunity of animals.The change of Paneth cell had related with intestine dysfunction.Recent studies provide evidence that Paneth cellα-defensin expression disorder may be a key pathogenic factor in inflammatory bowel disease.This article reviewed the distribution,morphology,biology characteristics of Paneth cell,biosynthesis and function of Paneth cellα-defensin.