Ce^(3+)对大白鼠和豚鼠心肌的影响

Effect of Ce3+ on Cardiac Muscle of Rat and Guinea Pig

研究了Ｃｅ３＋对离体豚鼠心房收缩、离体豚鼠乳头肌及在体大白鼠心肌动作电位的影响。浓度为００５ｍｍｏｌ·Ｌ－１的Ｃｅ３＋溶液可抑制豚鼠右心房的自律性和左心房的收缩。０１和０２ｍｍｏｌ·Ｌ－１Ｃｅ３＋溶液对豚鼠乳头肌动作电位时程影响不显著。０４ｍｍｏｌ·Ｌ－１Ｃｅ３＋对乳头肌动作电位时程有显著影响。长期用高浓度Ｃｅ３＋溶液饲养大白鼠，其心率显著降低，心肌动作电位时程显著增长，零相上升最大速率显著降低；

The effect of Ce3+ on cardiac muscle of rat and guinea pig was studied. In vitro, 005 mmolL-1 Ce3+ inhibited the contraction of guinea pig atria. The change of action potential duration(APD) of guinea pig myocardium exposed to 04 mmolL-1 Ce3+ was significant, and that exposed to 01 and 02 mmolL-1 Ce3+ was insignificant. Contrast to the control group, the APD of rat cardiac muscle after long time exposure to Ce3+ was significantly delayed in high dose, and that was insignificantly delayed in low dose. The results suggested that Ce3+ with long time exposure might affect the influx of Ca2+, Na+ and outflow of K+ for rat cardiac muscle.