摘要
采用了一锅法合成工艺,以乙酰乙酸乙酯和硫脲为起始原料,经过脱水、脱醇缩合成环得到6-甲基-2-硫脲嘧啶,其结构经1H NMR、IR和MS表征。最佳反应条件为:硫脲90 mmol,n(硫脲):n(乙酰乙酸乙酯):n(氢氧化钾)=1:2.30:2.32时,产物收率为96.64%。
6-Methyl-2-thiouracil was synthesized from ethyl acetoacetate and thiourea by one-pot method after dehydration,dealcoholization and cyclization.The structure was characterized by 1H NMR,IR,and EI-MS.The yield could arrive 97.09% under the following optimum reaction conditions when n（thiourea）： n（ethyl acetoacetate）： n（potassium hydroxide） was 1/2.30/2.32.
出处
《浙江化工》
CAS
2010年第12期8-9,24,共3页
Zhejiang Chemical Industry
