摘要
α-乙酰基环己酮是一种重要的医药中间体。环己酮和吗啡啉以有机溶剂甲苯为共沸剂,以对甲苯磺酸为催化剂,进行缩合反应生成烯胺,然后加入缚酸剂三乙胺,滴加乙酰氯和有机溶剂的混合物,烯胺与乙酰氯发生亲核加成反应,生成亚胺正离子,最后加入浓盐酸对亚胺正离子进行水解,生成研究产物2-乙酰基环己酮。产物结构经红外光谱、核磁共振氢谱分析验证与目标化合物的结构一致。该方法经济环保,简单易操作。
α-acetylcyclohexanone is an important pharmaceutical intermediate.With toluene as azeotropic agent and toluene-p-sulfonic acid as catalyst cyclohexanone and morpholine cocondensate,enamine was generated.And then it underwent nucleophillic addition with acetylchloride in presence of deacid reagent triethylamine to yield an imidic cation and finally underwent hydrolysis with concentrated hydrochloric acid to yield the target product α-acetylcyclohexanone.Structure of the compound was confirmed by both IR and NMR spectroscopy.This synthetic method is economical and environmentally benign and operator friendly.
出处
《常州大学学报（自然科学版）》
CAS
2010年第4期24-27,共4页
Journal of Changzhou University：Natural Science Edition
基金
常州大学科技基金项目(ZMF05020022)
