血清总胆汁酸在新生儿黄疸时浓度的变化及临床意义

目的探讨血清总胆汁酸(TBA)测定在新生儿生理性及病理性黄疸胆汁酸淤积时的变化及临床意义。方法采用循环酶速率法检测病理性黄疸72例、生理性黄疸59例、对照组56例血清中总胆汁酸(TBA)的水平并进行比较,同时进行其他肝功能相关项目测定。结果病理性黄疸组与其他2组比较TBA检测结果显著增高,差异有显著性(P<0.01)。结论血清总胆汁酸测定在新生儿黄疸的诊断中具有较高的特异性和灵敏性可以反应不同程度的胆汁淤积,是较为灵敏的肝实质损伤的指标,并优于肝功能相关项目检测,对新生儿黄疸的诊断和疗效观察有重要意义。

Objective To investigate the concentration changes and clinical significances of serum total bile acid（TBA） in the bile acid deposition of physiological and pathological neonatal jaundice.Methods The levels of serum TBA in 72 neonates with pathological jaundice,59 neonates with physiological jaundice,and in 56 normal neonates（control group） were detected by enzymatic cycling and kinetic assay and compared.Results The level of serum TBA in the pathological jaundice group was significantly higher than the other two groups（P〈0.01）.Conclusion With high specificity and sensitivity,serum TBA detection was a sensitive indicator for liver parenchyma injury in the diagnosis of neonatal jaundice,and it was important for the diagnosis and observation of the therapeutic effect.