炎琥宁联合利巴韦林治疗儿童手足口病重症早期临床疗效观察

Therapeutic effects of dehydroandrographolide succinate combined with ribavirin on children with hand-foot-and-mouth disease

目的探讨炎琥宁联合利巴韦林治疗儿童手足口病重症早期的疗效。方法将46例手足口病重症早期表现的患儿分为治疗组23例和对照组23例,2组均给予巴韦林及对症支持治疗,治疗组联合给予炎琥宁,10 mg/kg.d,静脉滴注,疗程5 d,观察2组临床症状(体温、皮疹、精神、易惊抖动)好转恢复时间等。结果 2组患儿均临床痊愈,治疗过程中无进展发生神经源性肺水肿、心力衰竭病例;治疗组较对照组热退时间,皮疹消退时间明显缩短,差异有统计学意义;2组间精神好转、惊跳抖动消失时间,住院总时间差异无统计学意义。结论炎琥宁联合利巴韦林治疗手足口病重症早期可使患儿热程缩短,皮疹消退较快,但对改善重症预后无明显正面影响。

Objective To evaluate the therapeutic effects of dehydroandrographolide succinate and ribavirin on children with the early severe tendencies of hand-foot-and-mouth disease.Methods Children（46 cases） with the early tendencies of hand-foot-and-mouth disease were divided randomly into two groups.All cases received ribavirin and therapies based on their symptoms,while the treatment group of 23 children received dehydroandrographolide succinate（10 mg.kg-1.d-1） for 5 days.Clinical symptom regression time or recovery time in two groups were observed after treatments.Results All children were recovered after treatments and no case develop into neurogenic pulmonary edema or cardiopulmonary collapse.The duration of fever was shorter in the treatment group;rashes on hands and feet faded more quickly than those of the control group.The difference between the two groups had statistical significance.However,there was no statistically significant differences between the two groups as for the time of mental improvement,disappearance of body shaking and hospital stay time.Conclusion Dehydroandrographolide succinate combined with ribavirin treatedchildren with hand-foodand mouth disease,the duration of fever was shorter,rashes on hands and feet more quickyly.