魔芋葡甘聚糖-尼莫地平药膜体外释放性能的初步探讨

In vitro Release Properties of Konjac Glucomannan-nimodipine Membrane

本文选用尼莫地平(nimodipine,NMP)作为模型药物,以魔芋葡甘聚糖(Konjac glucom annan,KGM)为材料制备KGM-NMP药膜,对其在体外不同介质和不同温度下的释药特性进行考察,初步探讨魔芋葡甘聚糖-尼莫地平药膜的体外释放性能。采用扫描电子显微镜观察药膜各个释放阶段的形态及表面结构,药膜呈胶束状,表面平整光滑,个别表面有凹凸状;用药物释放动力学方程拟合药物释放数据曲线,推导建立数学模型,同时结合电镜扫描结果分析,KGM-NMP药膜的溶蚀特性更符合零级动力学方程,释放机制为扩散和骨架溶蚀的协同作用。该药膜在体外具有明显的缓控释作用,24 h内释药稳定。

The in vitro release properties of NMP were analysised by konjac glucomannan membrane.In vitro drug release and erosion condition of the membrane were studied respectively in release media with different pH and temperature.And the shape and surface of the membrane were characterized by scanning electron microscopy（SEM）,which showed that the membrane were smooth except few membrane with accidented surface.Mathematic models were used to imitate the drug release,which showed that dissolution process of NMP from hydrophilic matrix conformed to zero-order release kinetics.The cumulative drug release was explained by the co-operation of diffusion and erosion.The KGM-NMP membran possessed sustained release characteristic,and the drug was released constantly during 24 h.