灰树花胞外多糖对四氯化碳致小鼠肝损伤的保护作用

Protective Effect of Exo-polysaccharides Produced by Grifola frondosa on Carbon Tetrachloride Induced Liver Injury in Mice

四氯化碳可导致小鼠急性肝损伤,采用灰树花胞外多糖(GFP)防治后,对其血清中丙氨酸氨基转移酶(ALT),天门冬氨酸氨基转移酶(AST)和过氧化氢酶活力(CAT)以及肝组织匀浆中的丙二醛(MDA)和乳酸脱氢酶(LDH)进行测定,与模型组相比较,灰树花胞外多糖治疗组ALT、AST、MDA、LDH活力明显降低,而CAT活力明显升高。通过组织切片染色可以直观的看出灰树花胞外多糖能显著减轻肝组织病理变化程度。结果显示GFP对CCL4致小鼠急性肝损伤具有保护作用。

Acute hepatic injury model was induced by CCl4 in mice to study the protective effect of exo-polysaccharides produced by Grifola frondosa（GFP）on experimental liver injury in mice.The activities of alanine aminotransfe（ALT）,aspartate aminotransferase（AST）,catalase（CAT） in serum,lactate dehydrogenase（LDH）,and the content of maleic dialdehyde（MDA） in the liver tissue were investigated,and the histological changes of liver were observed.GFP could decrease the serum activities of ALT,AST,and the activity of LDH,MDA content in liver tissue,but increase the serum activities of CAT of mice with acute hepatic injury induced by CCl4,and it could lessen the histological changes of liver.Consequently,we can see clearly that GFP showed protective effect on mice with acute hepatic injury.