摘要
从沙棘籽粕乙醇溶液中分离到三个生物碱,经波谱学方法及文献比较分别鉴定为5,11-二羟色胺(1)、5-羟色胺(2)和Shepherdine(3)。化合物1和3在沙棘中首次报道。利用体外培养乳鼠心肌细胞,建立心肌缺血/再灌注损伤模型,发现3个化合物对乳鼠心肌细胞缺血/再灌注(I/R)损伤有较好的保护作用。
Three alkaloids were isolated from the ethanol extract of Seed of Hippophae rhamnoides Linn and identified as 5-hydroxy-3-（2-Hydroxyethyl）indole（1）,5-hydroxytryptamine（2）,and shepherdine（3）by 1H and 13C NMR spectroscopic analyses.Neonatal rat cardiocytes were cultured and model of ischemic/reperfusion（I/R）was established.The results showed three alkaloids have protective effects against the neonatal rat cardiocytes ischemia/reperfusion injured,and compounds 1 and 3 were isolated for the first time from this plant.
出处
《天然产物研究与开发》
CAS
CSCD
2010年第6期937-939,共3页
Natural Product Research and Development
基金
国家科技支撑计划(2007BAD83B02)
关键词
沙棘
生物碱
沙棘碱
Hippophae rhamnoides Linn seed
alkaloid
ischemic/reperfusion
