天然产物5,6,7,3′,4′-五甲氧基异黄酮的合成(英文)

Synthesis of the Natural Product 5,6,7,3',4'-Pentamethoxyisoflavone

以3,4-二甲氧基苯乙酸和3,4,5-三甲氧基苯酚为原料,通过一条包括酯化反应、Fries重排、以及Vilsmeier-Haack反应等5步反应的路线合成了天然产物5,6,7,3′,4′-五甲氧基异黄酮。根据3,4,5-三甲氧基苯酚计算目标产物的总收率为76%,利用NMR及元素分析确证了化合物的结构。

The natural product 5,6,7,3＇,4＇-pentamethoxyisoflavone was synthesized by a 5-step synthetic protocol including esterification,Fries transformation,and Vilsmeier-Haack reaction with 3,4-dimethoxyphenylacetic acid and 3,4,5-trimethoxyphenol as the starting materials.The overall yield of the target compound was 76% based on 3,4,5-trimethoxyphenol.The structure of the natural isoflavone 5,6,7,3＇,4＇-pentamethoxyisoflavone was confirmed by NMR and elemental analysis.