过敏性紫癜患儿外周血中IL-6和TGF-β1水平临床意义

Clinical Significances of Serum IL-6 and TGF-β1 Level in Children with HSP

目的:通过观察过敏性紫癜(Henoch-Schonlein Purpura,HSP)患儿血清中IL-6和TGF-β1水平的变化,以探讨其在HSP发病机制中的意义.方法:选择HSP患儿48例和健康儿童28例,采用双抗体夹心ELISA法检测其IL-6和TGF-β1的水平,并对两组之间两个指标进行统计学分析.结果:HSP患儿急性期血清中IL-6、TGF-β1水平显著高于正常对照组,二者有统计学差异(t=6.090,p<0.05;t=7.162,p<0.05).结论:HSP患儿血清中IL-6水平显著升高,体现出Th2呈优势活化状态,Th1/Th2失衡;TGF-β1水平显著升高,提示体内出现保护性或调节性Th3功能增强.即HSP患儿体内细胞免疫功能紊乱,提示两者在该病发病机制中有着重要的作用,对过敏性紫癜发病机制的研究及指导治疗有重要价值.

Objective：To discuss the changes and clinical significances of interleukin-6（IL-6）and transforming growth factor-β1（TGF=β1）in children with Henoch-Schoenlein purpura（HSP）.Methods：The IL-6 and TGF-β 1 were detected in 48 children with HSP and 28 normal children by ELISA.The level of serum IL-6 and TGF-β1 in the two groups were compared and analysed by statistics.Results：The serum IL-6 level and TGF-β1 level in children with HSP are higher.Conclusion：The serum IL-6 level in acute phase of HSP is significantly increased than the normal control.The results suggested that Th2 had been activated,Th1/Th2 are unbalance.The serum TGF-β1 level in acute phase of HSP is significantly increased than the normal control,the results suggest that the protect function of Th3 has been enhanced.The function of cell-mediated immunity is turbulence.So the IL-6 and TGF-β1 play an crucial role in pathogenesis of HSP.