血清PSA、f-PSA/t-PSA在前列腺癌诊断中的意义

DIAGNOSTIC SIGNIFICANCE OF SERUM PSA AND F-PSA/T-PSA FOR PROSTATIC CANCER

目的探讨血清PSA、f-PSA/t-PSA在前列腺癌(PCa)诊断中的意义。方法回顾性分析51例前列腺癌与44例前列腺良性增生(BPH)患者血清PSA、f-PSA/t-PSA值在前列腺癌鉴别诊断中的意义。结果 PCa与BPH两组患者间PSA、f-PSA/t-PSA有显著差异(p<0.01)。当PSA介于4.0～10.0μg/L之间,两组患者间PSA水平无显著性差异(p>0.05),而f-PSA/t-PSA有显著性差异(p<0.01)。且PSA介于4.0～10.0μg/L之间,f-PSA/t-PSA分别为0.10、0.16、0.25时,对PCa诊断的灵敏度为37.3%、77.1%、95.4%;特异性为96.9%、82.8%、53.2%。结论 PCa患者PSA显著升高,f-PSA/t-PSA则显著降低。而PSA介于4.0～10.0μg/L之间,PSA无诊断意义,选择f-PSA/t-PSA为0.16作为临界值,对PCa的诊断有较高的灵敏度和特异性。

Objective To investigate the diagnostic significance of serum PSA and f-PSA/t-PSA for prostatic cancer（Pca）.Methods Serum PSA and f-PSA/t-PSA of 51 patients with prostatic cancer and 44 patients with benign prostate hyperplasia（BPH） were analyzed retrospectively.Results The differences o4f serum PSA and f-PSA/t-PSA between two groups were significant（p0.01）.When serum PSA was between 4.0～10.0 μg/L,the difference of serum PSA between two groups was not significant（p0.05）,but in serum f-PSA/t-PSA,the difference was significant（p0.01）.And When serum PSA was between 4.0～10.0 μg/L,serum f-PSA/t-PSA was 0.10,0.16,0.25 respectively,the sensitivity for diagnosing Pca were 37.3%,77.1%,95.4%,respectively,the specificity of them were 96.9%,82.8%,53.2%,respectively.Conclusion The level of serum PSA in patients with Pca significantly increased,Serum f-PSA/t-PSA significantly decreased.If serum PSA was between 4.0～10.0 μg/L,It was no valuable for diagnosing prostatic cancer.It has high sensitivity and specificity for diagnosing prostatic cancer（Pca） to select 0.16 as critical value of serum f-PSA/t-PSA.