氟比洛芬酯对异丙酚-瑞芬太尼全凭静脉麻醉深度的影响

Effect of flurbiprofen on the depth of anaesthesia during total intravenous anaesthesia with propofol-remifentanil

目的评价氟比洛芬酯对异丙酚-瑞芬太尼全凭静脉麻醉患者麻醉深度的影响。方法择期全身麻醉手术患者30例,ASAⅠ～Ⅱ级,麻醉深度采用脑电双频指数(BIS)和听觉诱发电位指数(AAI)监测,静脉注射咪唑安定0.05 mg/kg、异丙酚2 mg/kg、芬太尼3μg/kg、罗库溴铵1 mg/kg,行气管插管。术中异丙酚5 mg.kg-1.h-1、瑞芬太尼0.15μg.kg-1.min-1维持麻醉,维库溴铵间断加入维持肌松。调节麻醉药物输注速率使AAI值维持在20±5,BIS值维持在50±5。待各项麻醉监测指标稳定维持20 min后,静脉注射氟比洛芬酯1 mg/kg,分别记录氟比洛芬酯注射即刻?注射后5 min、10 min、15 min、20 min、30 min的AAI、BIS、平均动脉压(MAP)和心率(HR)值。结果给药后各时点患者的AAI、BIS、MAP和HR值与给药前相比较差异无统计学意义(P>0.05)。结论临床剂量的氟比洛芬酯在异丙酚-瑞芬太尼全凭静脉麻醉中对麻醉深度无明显影响。

Objective To evaluate the effect of flurbiprofen axetil on the depth of anaesthesia during total intravenous anaesthesia with propofol-remifentanil.Methods Thirty ASAⅠ-Ⅱ adult patients who undergoing elective surgery under total intravenous anaesthesia were studied.The sedation level was monitored using the electroencephalogram bispectral index（BIS） and auditory evoked potential index（AAI） device.Anesthesia were induced with midazolam 0.05 mg·kg^-1,propofol 2mg·kg^-1,fentanyl 3ug·kg^-1 and rocuronium 1mg·kg^-1 and maintained with propofol 5mg·kg^-1·h^-1,remifentanil 0.15ug·kg^-1·min^-1 and vecuronium.Doses for anaesthetics were adjusted to keep the the AAI value at 20±5,BIS value at 50±5.After 20 minutes of stable haemodynamics,BIS and AAI,patients were given flurbiprofen axetil 1mg/kg intravenously,AAI﹑BIS﹑MAP and HR were recorded before and 5,10,15,20,30 minutes after flurbiprofen axetil intravenously.Results The values of AAI﹑BIS﹑MAP and HR after flurbiprofen axetil intravenously were not significantly different from those values before flurbiprofen axetil intravenously.Conclusion Clinical dose of flurbiprofen axetil does not alter the depth of anaesthesia during total intravenous anaesthesia with propofol-remifentanil.