蠕虫免疫调控与“蠕虫疗法”

Helminth immunoregulation and "helminth therapy"

蠕虫是一类多细胞、借助肌肉伸缩蠕动的无脊椎动物。蠕虫感染是"卫生学假说"研究的主题。动物实验研究表明,蠕虫感染表现为特征性的Th2免疫应答,可抑制或消除Th1免疫应答,在建立长期慢性寄生虫感染的同时,减轻过敏和自身免疫性疾病损害的严重程度。本文综述了蠕虫免疫调控、蠕虫感染与过敏症和自身免疫性疾病、"蠕虫疗法"相关研究信息,为利用蠕虫免疫调控机制干预过敏和自身免疫性疾病探索有益途径。

A group of multi-cellular organisms,helminths are invertebrates that wriggle by contracting and flexing muscles on opposite sides of the body.Helminth infections are a major theme of the ＂hygiene hypothesis.＂ Animal studies of helminth infections have indicated a characteristic Th2 immune response that may eliminate or inhibit the Th1 response;helminth infections tend to be long-term chronic parasitic infections and reduce the severity of allergies and autoimmune diseases at the same time.This paper reviews the relevant information concerning helminth immunoregulation,helminth infection and allergies,autoimmunity,and ＂helminth therapy,＂ and this paper examines new ways to use the mechanisms of immunoregulation by helminths to intervene in allergies and autoimmune diseases.