重型颅脑损伤患者早期肠内营养对C-反应蛋白的影响及临床意义

Influence severe craniocerebral injury patients with early enteral nutrition on C-reactive protein and clinical significance

目的:观察早期肠内营养(EEN)支持对重型颅脑损伤患者血清中C反应蛋白(CRP)含量变化的影响,探讨早期肠内营养治疗能否减轻全身炎症反应及其临床意义。方法:将60例神经外科重型颅脑损伤患者随机分为治疗组即早期肠内营养(EEN)组和对照组即早期胃肠外营养(PN)组,各30例,入院48 h内给予不同方法的营养支持。测定入院后第1、3、5、7天和第14天血清中CRP的含量。结果:两组患者血清CRP含量均呈下降趋势,但EEN组下降幅度更显著,伤后第5、7、14天EEN组血清CRP含量明显低于PN组,差异有统计学意义(P<0.05)。结论:早期肠内营养支持对重型颅脑损伤患者可减轻其全身炎症反应,促进患者早期恢复十分有益。

Objective： To observe the effect of early enteral nutrition（EEN） on content of C-reactive protein（CRP） in the serum in order to explore the clinical significance of EEN in relieving systemic inflammatory response for the patient with severe craniocerebral injury.Methods： 60 patients with severe craniocerebral injury were randomly divided into two groups,the treatment group（early enteral nutrition,EEN） and the control group（early parenteral nutrition,PN）,each group 30 cases,different nutrition support was given to all the patients within 48 hours after admission to the hospital.The serum CRP concentrations in all the patients were determined on the 1st day,3rd day,5th day and 7th day respectively after injury.Results： The content of the serum CRP in both groups were gradually decreased,but the concentrations of serum CRP were significantly lower in the EEN group on the 5th day,7th day and 14th day after injury than those in PN group.The difference was statistically significant（P0.05）.Conclusion： EEN support may reduce systemic inflammatory response,which is good for early recoveries of the patients with severe craniocerebral injury.