地塞米松在口腔颌面部手术中的临床研究

Clinical research on Dexamethasone in oral and maxillofacial surgery

目的:探讨地塞米松在防止或减轻术后肿胀和感染中的作用。方法:将100例行口腔颌面部清创缝合手术患者随机分为两组,均使用抗生素,治疗组使用地塞米松,对照组不使用地塞米松,对术后肿胀和感染等情况进行对比研究。结果:治疗组的术后肿胀、疼痛、感染和瘢痕发生率分别为44%、54%、6%和18%,对照组的术后肿胀、疼痛、感染和瘢痕发生率分别为92%、80%、22%和34%,对照组的发生率明显高于治疗组,两组比较经统计学分析,肿胀、疼痛和感染方面差异有统计学意义(P<0.05)。结论:在掌握好适应证、禁忌证,同时使用抗生素的前提下,合理适量地使用地塞米松,对防止和减轻术后肿胀、疼痛、感染等并发症有积极的作用。

Objective： To study the effect of Dexamethasone on the prevention or reduction of swelling and infection after surgery.Methods： 100 patients with oral and maxillofacial surgical debridement suture were randomly divided into two groups used antibiotics,treatment group with the use of Dexamethasone and control group without the use of Dexamethasone,swelling and infection etc.were compared between two groups.Results： Postoperative swelling,pain,infection and scar incidence were 44%,54%,6% and 18% respectively in treatment group,92%,80%,22% and 34% respectively in the control group,swelling,pain and infection incidence of control group were significantly higher than those of the treatment group,there were significant differences（P0.05）.Conclusion： To master the indications,contraindications,and use of antibiotics,provide that a reasonable amount for the use of Dexamethasone in the prevention and reduction of postoperative swelling,pain,infections and other complications have positive effects.