三聚氰胺在奶山羊体内药代动力学的研究

Studies on the Pharmacokinetics of Melamine in Dairy Goat

本试验旨在研究三聚氰胺在奶山羊体内的药代动力学过程。通过采用6只奶山羊单剂量快速静脉注射三聚氰胺6.13mg·kg-1,24h内不同时间11次颈静脉采血,利用高效液相色谱法测定三聚氰胺浓度,3P97药动学计算软件处理血浆药物浓度—时间数据。结果显示:三聚氰胺在奶山羊体内呈二室开放模型。主要药动学参数:表观分布容积Vd=(0.03±0.01)L·kg-1、消除半衰期t1/2β=(3.64±0.02)h、药时曲线下面积AUC=(41.96±0.52)μg·h·mL-1、体消除率CL=(0.14±0.01)L·kg-1·h-1。结果提示,三聚氰胺在奶山羊体内可以快速的被肾脏清除,且不会在其他组织器官中广泛分布。

This experiment was conducted to study the pharmacokinetics of melamine in dairy goat.A single intravenous administration of the melamine at the dose of 6.13 mg·kg-1bw to 6 dairy goats.Blood samples were collected at different intervals after administration and concentrations of melamine were determined by HPLC method.The plasma concentration-time data of melamine was analyzed by Pharmaceutical 3P97.The results showed that Two-compartment open model was the optimum one of melamine in the dairy goats.The main pharmacokinetic parameters were as follows：Vd was（0.03±0.01） L·kg-1,t1/2β was（3.64±0.02） h,AUC was（41.96±0.52） μg·h·mL-1,CL was（0.14±0.01） L·kg-1·h-1.The results indicated that the distribution of melamine in dairy goat was limit,and the elimination of melamine was rapid.