微波辐射下稀土复合固体超强酸催化合成抑芽酸酯

Synthesis of methyl 1-naphthylacetate catalyzed by rare earth composite solid superacid under microwave irradiation

借助微波辐射技术,以稀土复合固体超强酸Nd3+-SO42-/ZrO2作催化剂,1-萘乙酸和甲醇为原料合成了抑芽酸酯。通过单因素和正交实验,探讨了影响酯产率的主要因素,确定了最佳合成条件:醇酸摩尔比为16∶1,催化剂用量为醇酸总质量的11%,微波输出功率为480 W,辐射时间为12 min。在此优化条件下,抑芽酸酯的产率可达97%以上。实验结果表明:稀土复合固体超强酸Nd3+-SO42-/ZrO2对抑芽酸酯的合成具有良好的催化活性,同时微波辐射加快了反应进程。

Methyl 1-naphthylacetate（MENA） was synthesized with 1-naphthylacetic acid and methanol as raw materials and rare earth composite solid superacid Nd^3＋-SO4^2-/ZrO2 as catalyst under microwave irradiation.The factors influencing the synthesis were discussed by single factor and orthogonal experiments and the optimum conditions were determined as follows： molar ratio of methanol to 1-naphthylacetic acid of 16：1,mass ratio of catalyst to total feedstock of 11%,microwave power of 480 W and microwave irradiation time of 12 min.Under the optimized conditions,the yield of ester was more than 97%.The results showed that Nd^3＋-SO4^2-/ZrO2 was an excellent catalyst for synthesizing MENA and microwave irradiation could enhance reaction rate.