2型糖尿病患者胰岛素抵抗与非酒精性脂肪肝的关系研究

Study on Relationship between Insulin Resistance and Non-alcoholic Fatty Liver Disease in Patients with Type 2 Diabetes Mellitus

目的探讨2型糖尿病患者胰岛素抵抗指数与非酒精性脂肪肝的关系。方法检测54名确诊为2型糖尿病合并非酒精性脂肪肝患者的空腹血糖(FPG)、空腹血清胰岛素(FInS)、三酰甘油(TG)、胆固醇(TC)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)等指标,计算胰岛素抵抗指数(HOMA-IR),并与38例单纯2型糖尿病患者作对照。结果 2型糖尿病伴非酒精性脂肪肝病患者的FPG、FInS、HOMA-IR、TC、TG、LDL均显著高于对照组,差异有统计学意义(P<0.05或P<0.01)。结论型糖尿病伴非酒精性脂肪肝患者存在明显的胰岛素抵抗和脂代谢紊乱。控制血糖、改善胰岛素抵抗及脂代谢紊乱对预防和治疗2型糖尿病伴发非酒精性脂肪肝具有重要意义。

Objective To investigate the relationship between insulin resistance and non-alcoholic fatty liver disease（NAFLD）in patients with type 2 diabetes mellitus（T2DM）.Methods The levels of fasting plasma glucoes（FPG）,fasting insulin（FInS）,triglycerides（TG）,total cholesterol（TC）,high density lipoprotein（HDL） and low density lipoprotein（LDL） were detected,the insulin resistance index（HOMA – IR） was calculated in 54 diagnosed patients with T2DM and NAFLD,and compared with 38 diagnosed patients with T2DM without NAFLD.Results The levels of plasma FPG,FInS,HOMA – IR,TG,TC,LDL in patients with T2DM and NAFLD were significantly higher than the control group（P0.05 or P0.01）.Conclusion There are significant insulin resistance and lipid metabolic disorder in patients with T2DM and NAFLD.It is necessary to take measures to control the patient＇s blood sugar,reduce insulin resistance and improve lipid metabolism for the prevention and treatment of DAFLD in T2DM.