学龄期癫癎患儿认知功能状况与相关因素分析

Change of cognitive function and analysis of related factors in schoo-age children with epilepsy

目的探讨学龄期癫癎患儿的认知功能及其相关因素的关系。方法调查新近确诊的38例发作控制在75%以上且时间超过一年的学龄期癫癎患儿的临床资料,运用韦氏儿童智力量表测定所有癫癎患儿治疗前后的认知功能,同30例正常儿童进行对照,并进行统计学分析。结果癫癎患儿的智商较正常对照组明显下降(P<0.01);癫癎患儿治疗后总智商与病程、发作频率及每次发作时间呈正相关(γ=0.523,P=0.013;γ=0.432,P=0.043;γ=0.487,P=0.048),与发病年龄呈负相关(γ=-0.452,P=0.046);癫癎患儿单药治疗控制发作1年后平均智商从81.97提高到90.93,具有统计学意义(P<0.05),二药治疗平均智商从85.89提高到88.78,无统计学意义(P>0.05)。结论癫癎患儿智能存在不同程度的缺陷,与发病年龄、病程、发作频率、发作持续时间有关,药物控制癫癎发作对患儿认知功能有益。

Objective To study the cognitive function and related factors in school-age patients with epilepsy. Methods To investigate the data of 38 cases of seizure control in more than 75% and more than one year of school-age children with epilepsy clinical ther are diaghosed in our hospital., all children with epilepsy before and after treatment cognitive function were measured by Wechsler Intelligence Scale for Children compared with 30 normal control children, and conduct the final statistical analysis.Results IQ of children with epilepsy compared with normal control group decreased significantly（P0.01）; epilepsy after treatment in patients with a total IQ and course of disease, seizure frequency, time of each attack was positively correlated （γ= 0.523, P = 0.013; γ= 0.432, P = 0.043; γ= 0.487, P = 0.048）, and the age at onset was negatively correlated （γ=-0.452, P= 0.046）; epileptic seizures in children with single-drug therapy to manage are year after the average IQ from 81.97 to 90.93,there was statistically significant （P0.05）, the average IQ using two drugs from 85.89 to 88.78, no statistical significance .Conclusion Intelligence in children with epilepsy are different degrees of impairment, and the at onset and duration, seizure frequency and duration of each attack is related to it,drug control seizures in children is benefits on the cognitive function.