慢性阻塞性肺疾病患者血清中白细胞介素-10、肿瘤坏死因子-α、转化生长因子-β的变化

Changes of serum interleukin-10,tumor necrosis factor-α and transforming growth factor-β in chronic obstructive pulmonary disease

目的:探讨细胞因子白介素-10(interleukin-10,IL-10)、肿瘤坏死因子-α(tumor necrosis factor-alpha,TNF-α)、转化生长因子-β(transforming growth factor-beta,TGF-β)在慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)发病机制及加重过程中的作用。方法:采用ELISA测定COPD急性加重期、缓解期及健康对照组血清IL-10、TNF-α、TGF-β水平。结果:COPD急性加重期及缓解期患者血清IL-10水平均低于正常对照组(P<0.01);COPD急性加重期及缓解期组TNF-α水平明显升高,均高于正常对照组(P<0.01);COPD急性加重期血清TGF-β浓度均高于缓解期及正常对照组(P<0.01),但缓解期与正常对照组差异无统计学意义(P>0.05)。COPD急性加重期血清TGF-β水平与IL-10呈正相关关系。结论:IL-10、TNF-α、TGF-β参与COPD发病机制及急性加重过程。IL-10作为炎症抑制因子,其血清水平降低,可能在COPD气道炎症反应以及炎症加剧的过程中起着重要作用。

Objective：To investigate the effects of interleukin-10（IL-10）,tumor necrosis factor-α（TNF-α）,and transforming growth factor-β（TGF-β） in pathogenesis and aggravating phase of chronic obstructive pulmonary disease（COPD）.Methods：The serum contents of IL-10,TNF-α and TGF-β in acute exacerbation,catabasis phases of COPD and health control group were determeined by enzyme linked immunosorbent assay.Results：The levels of serum IL-10 in acute exacerbation and catabasis phases of COPD were lower than in normal control group（P0.01）;the levels of serum TNF-α of in acute exacerbation and catabasis phases of COPD were significantly higher than in normal control group（P0.01）;the content of serum TGF-β in acute exacerbation phase of COPD was higher than in normal control group and COPD catabasis group,but there was no significant difference between COPD catabasis phase and normal control group（P0.05）.TGF-β was positively correlated with IL-10 in COPD acute exacerbation phase.Conclusions：IL-10,TNF-α and TGF-β are all involved participate in the procedure of COPD pathogenesis and aggravating phase.The content of serum IL-10 in COPD is depressed,which maybe plays an important role in inflammatory reaction and aggravating phase of COPD.