基于近红外光电技术的脑水肿无创监测方法

Monitoring Method for Brain Edema Based on Near-infrared Spectroscopy

提出了基于近红外光电技术的脑水肿无创监测方法,对大鼠脑水肿的程度进行无创监测.阐述了监测设备的测量原理和系统组成,并对大鼠实验数据结果进行了分析.监测系统光源选用760 nm和程序850 nm的双波长发光二极管,通过恒流源电路驱动进行驱动.选用OPT101作为检测器,用锁相放大电路和滤波电路对所测信号进行处理.在LabVIEW环境下通过数据采集卡进行数据采集,并进行后期处理,该系统能够实时测量大鼠脑组织的血氧变化.利用该系统测量脑水肿模型的大鼠,分析了光强、血氧参量的变化与脑水肿变化的关系.研究结果表明近红外光电技术可应用于对大鼠脑水肿程度进行无损监测.

A noninvasive monitoring method for brain edema based on near infrared photoelectric detection technology is proposed.The measurement principles and system composition of the monitoring instrument are studied.The light source of the instrument is 760 nm and 850 nm dual-wavelength LED,which is driven by constant current source module.The light signal,scattered from the tissue,is detected by OPT101.Then the signal is processed by phase-locked amplifier and filter circuit.The filtered data are sampled by data acquisition card and processed in the LabVIEW environment in computer.The proposed system can monitor the changes in the brain of hemoglobin on real time.The system is used to monitor the changes of light intensity and blood oxygen content of the model of brain edema in mouse.The relationship between the changes of light intensity and oxygen parameters and brain edema is studied.The experimental results show that the near infrared photoelectric detection technology can be used as the noninvasive monitoring method for brain edema.