K88菌毛及其在仔猪断奶腹泻预防制剂开发中的应用

K88 fimbriae and its application in development of new vaccines against post-weaning diarrhea in piglets

K88大肠杆菌是引起仔猪断奶后腹泻(PWD)的主要病原。现有商业疫苗通过母猪免疫能有效控制新生仔猪大肠杆菌性腹泻,而对PWD却难以奏效。口服疫苗能诱导肠粘膜产生局部抗体,阻止致病性大肠杆菌的粘附,进而预防PWD。从分子水平认识K88菌毛及其受体的生物学特性,对口服疫苗的研制具有重要意义。文章概述国内外关于K88菌毛基本特性、蛋白亚基及受体的研究,就K88菌毛在PWD预防制剂研发中的应用的进展作了综述,并探讨分析了口服基因工程细菌疫苗和植物疫苗的前景。

E.coli K88 is the main pathogen of post-weaning diarrhea（PWD）.The existing commercial vaccines could effectively control diarrhea caused by E.coli in newborn piglets from immuning sow,while it was unlikely effective to PWD.Oral vaccine could induce antibodies produced in local mucosal,prevent E.coli adhere to intestinal epithelium,thereby prevent PWD.To study the biological characteristics of K88 and its receptors at molecular level was important to develop oral vaccine.The progresses in the basic characteristics,protein subunits and receptors of K88 fimbriae at home and abroad were decribed,furthermore,the application prospect of engineering bacteria vaccine and plant-based vaccine were discussed.