小柴胡汤联合水飞蓟素治疗慢性乙型肝炎肝纤维化疗效分析

Analysis of the clinical effect of sho-saiko-to combined with silymarin on liver fibrosis due to chronic hepatitis B

目的观察小柴胡汤和水飞蓟素联用治疗慢性乙型肝炎肝纤维化的临床疗效。方法90例慢性乙型肝炎肝纤维化患者随机分为两组，治疗组50例服用小柴胡汤和水飞蓟素，对照组40例服用水飞蓟素，疗程均为6个月。观察两组用药前后肝功能、血清肝纤维化及乙肝病毒标志物指标变化。结果治疗组肝功能及血清肝纤维化指标均有明显改善（P〈0．01或P〈0．05），对乙肝病毒的清除作用也优于对照组（P〈0．05）。结论小柴胡汤和水飞蓟索联用对慢性乙型肝炎肝纤维化具有明确的临床意义。

Objective To evaluate the therapeutic effect of sho-saiko-to and silymarin on liver fibrosis due to chronic hepatitis B. Methods 90 patients with liver fibrosis due to chronic hepatitis B virus （HBV） were randomly divided into therapy group and control group. 50 patients in therapy group were given sho-saoko-to and silymarin; While 40 patients in control group were given silymarin only ,they were all treated for 6 months. The changes were observed including liver function, serum liver fibrosis and virology indexes before and after treatment in two groups. Resuits Indexes of liver function and serum liver fibrosis in therapy group were improved obviously （ P 〈 0. 05 or P 〈 0. 01 ）, while better clearance to HBV is comparable to control group （ P 〈 0, 05 ）. Conclusion The treatment with sho-saiko-to combined silymarin on liver fibrosis due to chronic hepatitis B had explicit clinical effect.