不同剂量氯胺酮复合异丙酚用于无痛人工流产术的临床研究

Clinical study of different dosage of Ketamine Combined with Propofol on painless Induced Abortion

目的探讨合理安全麻醉诱导药物配伍在无痛人工流术中的应用。方法120冽无痛人工流术患者，随机双盲法分为6组，P组为对照组，给予异丙酚3．5mg／kg；按照氯胺酮不同剂量0．1mg／kg、0．2mg／kg、0．3mg／kg、0．4mg／kg、0．5mg／kg，分别分为K1、K2、K3、K4、K5组，每组均与异丙酚3．5mg／kg配伍。观察血流动力学相关参数、镇痛效果、意识消失时间、意识恢复时间、定向力恢复时间、呼吸抑制发生率、不良反应、离院时间。结果时间数据及不良反应发率K5组与K3组差异有统计学意义（P〈0．05）；镇痛优良率K1、K4、K5组与对照组差异有统计学意义（P〈0．05）。结论氯胺酮0．3mg／kg复合异丙酚麻醉是无痛人流术的理想选择。

Objective To explore a reasonable and secure anesthesia induction in painless induced abortion. Methods 120 patients of painless induced abortion were randomly divided into six groups, control group was injected with Propofol 3.5mg/kg through vein,besides given Propofol 3.5mg/kg,other 5 groups were injected with ketamine 0. 1 mg/kg,0.2mg/kg,0. 3mg/kg,0. 4mg/kg,0.5 mg/kg through vein respectively. The parameter of hemodynamics, effect of analgesia, time of unconsciousness, recovery time of consciousness, recovery time of orientation, incidence of respiratory depression, side effect, time of discharge from hospital were observed. Results The recorded time and incidence of side effect have statistical significance between group of ketamine 0. 5mg/kg and group of ketamine 0. 3mg/ kg（P 〈 0. 05） ; effect of analgesia have statistical significance between group of ketamine 0. 3mg/kg,0.4mg/kg, 0. 5mg/kg and control group. Conclusion Ketamine 0. 3mg/kg combined with Propofol is an ideal choice of painless induced abortion.