2型糖尿病患者抗炎治疗前后相关指标分析

The relevant indicators of anti-inflammatory treatment In patients with type 2 diabetes

目的探讨2型糖尿病（T2DM）患者血清脂联素（APN）与炎性因子的相关性，并观察抗炎药物对糖尿病患者的疗效。方法将2型糖尿病患者分为T2DM合并血管病变组（A组）53例，T2DM无血管病变组（B组）47例，以健康人30例为对照组。分别检测抗炎治疗前后各组胰岛素、糖化血红蛋白（HbAlc）、血脂（1ipids）、游离脂肪酸（FFA）、C-反应蛋白（CRP）、APN、瘦素（Leptin）及肿瘤坏死因子（TNF-α）、胰岛素敏感性指数（ISI）及胰岛素抵抗指数（IR）等。结果ISI、IR、FFA、CRP、APN、Leptin、TNF-α含量均高于对照组（均P〈0．05）；抗炎治疗后明显下降（均P〈0．05）；APN平与HbAlc、HOMA-IR、CRP及TNF—α呈显著负相关（均P〈0．05）。结论APN是T2DM和动脉粥样硬化的保护性因子，抗炎治疗可能改善T2DM的预后。

Objective To investigate the correlation between serum adiponectin level and inflammatory factors in patients with type 2 diabetes melhtus（T2DM）. Methods In our hospital out-patient and patients with T2DM were divided into combined macrovascular T2DM group（ A group） 53 cases;T2DM without macroangi-opathy group（ B group） 47 cases; 30 cases of healthy people as control group. The contents of insulin, glycosylated hemoglobin （HbAlc） ,blood lipids ,free fatty acids（FFA） ,C-reactive protein（CRP） ,adiponectin（APN） ,leptin and tumor necrosis factor（TNF-α） ,insulin sensitivity index（ISI） and insulin resistance index（IR） were detected. Results ISI,IR, FFA, CRP, APN, Leptin, TNF-α levels were higher（ P 〈 0. 05 ）;anti-inflammatory treatment was significantly decreased（all P 〈 0.05 ）;APN level and HbAle, HOMA-IR, CRP,TNF-α was significantly negatively correlated（ P 〈 0. 05）. Conclusion APN is a T2DM and atherosclerosis protection factor, anti-inflammatory treatment may improve the prognosis of T2DM.