2008-2009年基层医院常见病原菌的分布及耐药性分析

Distribution and drug resistance of common pathogenic bacteria in grass-roots hospitals from 2008 to 2009

目的了解基层医院常见病原菌的分布及耐药特征,为临床治疗提供参考依据。方法采用K-B法进行药敏试验,参照CLSI标准判断药敏结果。结果 2008-2009年医院临床分离的588株细菌中,革兰阳性球菌占23.5%,革兰阴性杆菌占76.5%;MRSA和MRCNS分别占37.5%和77.6%;大肠埃希菌和克雷伯菌属产ESBLs菌株检出率为65.2%和54.5%。结论医院常见病原菌表现为多药耐药,应合理应用抗菌药物,延缓新的耐药菌株产生与扩散。

OBJECTIVE To understand flora distribution and drug-resistance in common pathogenic bacteria in grass-roots hospitals and provide the reference for clinical treatment. METHODS The susceptibility test was performed by K-B methods. The susceptibility results were analyzed according to CLSI. RESULTS Of 588 isolates from 2008 to 2009, Gram positive coccus and Gram negative bacilli accounted for 23. 5% and 76. 5%, respectively. The methicillin resistant Staphylococcus aureus （MRSA） and methicillin resistant coagulase negative Staphylococcus （MRCNS） accounted for 37. 5% and 77. 6%, respectively. The detection rates of extended spectrum β-lactamases （ESBLs） producing Escherichia coli and Klebsiella were 65.2% and 54.5%, respectively. CONCLUSION The common pathogenic bacteria present the multi-drug resistance. The reasonable antibiotics should be applied to prevent the occurrence and spreading of resistant strains.