重症监护病房医院感染铜绿假单胞菌耐药性分析

Drug resistance of pseudomonas aeruginosa causing nosocomial infections in ICU

目的探讨重症监护病房(ICU)医院感染铜绿假单胞菌(PAE)的耐药现状,为临床医师诊断与治疗提供科学依据。方法 PAE采用MicroScan AutoSCAN4自动微生物鉴定系统进行鉴定,用K-B法进行药物敏感试验并统计耐药率。结果 223株PAE对常用抗菌药物均产生了不同的耐药性,对碳青霉烯类抗菌药物亚胺培南和美罗培南耐药率分别为15.2%和14.3%。结论医院ICU PAE的耐药性已十分严重,必须重视耐药菌株的监测,预防与控制ICU医院感染的发生。

OBJECTIVE To approach the antimicrobial resistance of Pseudomonas aeruginosa in intensive care unit, to provide scientific evidence for clinical diagnosis and treatment. METHODS MicroScan AutoSCAN4 system was used to identify PAE. The antimicrobial susceptibility testing in vitro was performed by K-B me,hods. RESULTS Totally 223 isolates were resistant to commonly used antibiotics to different degrees. The drug resistant rates to carbapenems, such as imipenem and meropenem, were 15.2 % and 14.3 %, respectively. CONCLUSION The drug resistance of PAE in ICU is very serious. We should focus on the monitoring to resistant strains to prevent and control the occurrence of nosocomial infections in ICU.