泌尿系感染真菌分布及耐药性分析

Distribution and drug resistance of fungi causing urinary tract infections

目的了解泌尿系真菌感染的菌株分布及耐药率,为临床合理选择抗菌药物提供依据。方法对2009年1-12月送检的1513份尿培养标本进行回顾性调查分析。结果共分离139株真菌,检出率为9.19%,前3位菌株分别是热带假丝酵母菌73株(52.52%)、白色假丝酵母菌38株(27.34%)、光滑假丝酵母菌13株(9.35%),所有菌株对两性霉素B、5-氟胞嘧啶100.00%敏感,对氟康唑、伏立康唑、伊曲康唑的耐药率分别是36.69%、41.73%、46.76%。结论热带假丝酵母菌的分离率及对氟康唑、伏立康唑、伊曲康唑的耐药率呈逐年上升趋势,应引起临床医师的高度重视。

OBJECTIVE To understand the fungal pathogen distribution and drug resistance of fungal infection in urinary tract infection, in order to provide evidence for reasonable selection of antibiotics. METHODS Totally 1513 samples of urine culture from Jan. 2009 to Dee. 2009 were retrospectively analyzed. RESULTS A total of 139 strains of fungi were isolated, accounted for 9.19%. Among which, C. tropicalis, Candida albicans and C. glabrata accounted for 73 strains（52. 52%）,38 strains（27. 34%） and 13 strains （9. 35%）, respectively. All the fungal strains were sensitive to amphotericin B and 5-fluorocytosine, but the drug resistant rate to fluconazole, voriconazole and ITCaconazole were 36.69 % ,41.73 % and 46.76 %, respectively. CONCLUSION The isolated rate of C. tropicalis and the resistant rates to fluconazole,voriconazole and ITCaconazole are increasing year by year. Therefore,great attention should be aroused in the clinical doctors.