老年患者假丝酵母菌性肺炎的菌群分布及耐药性调查

Flora distribution and drug resistance of candida causing pneumonia in senile patients

目的探讨老年患者假丝酵母菌性肺炎的菌群分布及耐药性,为临床治疗用药提供试验依据。方法病例筛选严格参照卫生部《医院感染诊断标准》,假丝酵母菌属分离与鉴定按《全国临床检验操作规程》进行;药物敏感试验采用K-B法。结果 189株假丝酵母菌中,白色假丝酵母菌居首位,占63.5%,热带假丝酵母菌居第2位,占16.4%;189株假丝酵母菌对5种常用抗真菌药物的耐药率均<16.7%,其中两性霉素B、制霉菌素显示了100.0%的抗菌活性。结论临床对疑为真菌性肺炎的患者必须及时进行真菌培养,以早期发现病原性真菌和选择有效的抗真菌药物进行治疗。

OBJECTIVE To study the flora distribution and drug-resistance of fungal pneumonia in senile patients and to provide the reference for clinically reasonable therapy. METHODS The cases were selected in accordance with Diagnosis Standard of Hospital Acquired Infection. Candida mycoderma were isolated and identified according to the National Guide to Clinical Laboratory Procedures. The susceptibility testing was performed by K-B methods. RESULTS Among 189 strains of eandida mycoderma, Canidia albicans ranked the top, accounting for 63.5%. Then eandida tropicalis ranked the second, accounting for 16.4%. The drug-resistance rates of five commonly used antifungal drugs were all below 16. 7%. And all isolates were sensitive to amphotericin B and anticandine. CONCLUSION The fungal cultivation should be performed for the patients with suspected fungal pneumonia in time in order to discover nosopoietic fungus and apply effective antifungal agents at early stage.