黄连-厚朴配伍比例对和厚朴酚、厚朴酚溶出的影响

Influence of Different Compatibilities between Coptidis Rhizoma and Magnoliae Officinalis Cortex on Dissolution of Honokiol and Magnolol

目的:探讨黄连-厚朴酸碱药对不同配伍比例对和厚朴酚、厚朴酚溶出的影响。方法:采用高效液相色谱法测定黄连-厚朴药对煎煮液中和厚朴酚及厚朴酚的含量。结果:和厚朴酚在黄连∶厚朴=1∶3时溶出最多,厚朴酚在黄连∶厚朴=1∶1时溶出最多,两者总量在黄连∶厚朴1∶1时最高,2∶1时最低。结论:黄连-厚朴不同配伍比例对和厚朴酚及厚朴酚的溶出有影响,可能与黄连中的生物碱有关。

Objective：To study the influence of different compatibilities between Coptidis Rhizoma and Magnoliae Officinalis Cortex on dissolution of honokiol and magnolol.Method：High performance liquid chromatography was used to determine the content of honokiol and magnolol in all decoctions of Coptidis Rhizoma and Magnoliae Officinalis Cortex.Result：The maximum content of honokiol and magnolol was extrated when the ratio of Coptis to Magnolia was 1∶ 3 and 1∶ 1 respectively.The maximun total content of both components was extracted when the ratio was 1∶ 1 and the minimum when the ratio was 2∶ 1.Conclusion：Different compatibilities ratios between Coptidis Rhizoma and Magnolia Officinalis Cortex affected the dissolution of honokiol and magnolol,and it was probably related to the berberine alkaloids in Coptidis Rhizoma.