茴香枳术汤对大鼠粘连性肠梗阻腹部立位平片的影响

Effects of Huixiangzhizhu Soup on Abdominal Verticalposition Plain Film Radiography in Rats with Adhesive Intestinal Obstruction

目的:观察茴香枳术汤对大鼠粘连性肠梗阻腹部立位平片的影响,为深入探讨茴香枳术汤对粘连性肠梗阻的作用机制提供实验依据。方法:制备大鼠粘连性肠梗阻模型,随机分为正常组、模型组、大承气汤组、茴香枳术汤低、中、高剂量组。正常组和模型组两组灌服生理盐水0.01 mL·g-1,DS组灌服1.43 g·mL-1大承气汤0.01 mL·g-1,HX-SL,HX-SM,HX-SH 3组分别灌服1.13,2.25,3.38 g·mL-1的茴香枳术汤汤液0.01 mL·g-1。给予相应药物治疗,分别于治疗后第3,5,7天,共3个时间点,每时间点6只;腹腔麻醉后,拍摄腹部立位X线平片,观察肠梗阻的变化。结果:与正常组比较,模型组大鼠有大量积气积液,可见明显的气液平面,肠管扩张;与模型组比较,大承气汤组、茴香枳术汤低剂量组、茴香枳术汤中剂量组和茴香枳术汤高剂量组积气积液消失,肠管恢复正常,气液平面消失,肠梗阻缓解。结论:茴香枳术汤具有良好的治疗粘连性肠梗阻的作用。

Objective：To observe the effects of Huixiang Zhizhu soup（HX-S） on abdominal verticalposition plain film radiography in rats with adhesive intestinal obstruction,and provide experimental evidence for the realitionship of abdominal morphological features change with the adhesive intestinal obstruction of HX-S.Method： The Wister rat model of adhesive intestinal obstruction.One hundred and eight rats were randomLy divided into the normal group,model group,Dachengqi soup（DS）group,HX-S low dosage（HX-SL）group,HX-S middle dosage（HX-SM）group and HX-S high dosage（HX-SH）group.Succeed in the model,each group were given medicine.The rats were narcotized after three days,five days and seven days adopt to film abdominal verticalposition X plain,with 6 rats in each subgroup.Observe the change of adhesive intestinal obstruction.Result： Compared with those in normal group,there are some pneumatosis and hydrops,intestinal dilatation,gas and liquid plane obxiously in model group;Compared with those in model group,the level of pneumatosis and hydrops decreased obviously,intestinal recovery,pneumatosis and hydrops disappeared in DS group,HX-SL group,HX-SM group and HX-SH group,intestinal obstruction remission.Conclusion：HX-S has good action effect in rats with adhesive intestinal obstruction.