(±)二氢槲皮素的全合成

Total synthesis of (±) taxifolin

以2,4,6-三羟基苯乙酮与3,4-二羟基苯甲醛经甲氧甲氧基保护羟基、羟醛缩合、环氧化及脱保护关环反应制得二氢槲皮素。此方法是关于二氢槲皮素的全合成方法,相对天然产物提取方法,操作方便简洁,成本较低,有很好的应用价值。目标化合物经核磁共振氢谱、碳谱、红外和质谱分析确认。

Taxifolin was totally synthesized from 3,4-dihydroxybenzaldehyde and 1-（2,4,6-trihydroxyphenyl） ethanone via reactions involving hydroxy protection,aldol condensation,epoxidation,and deprotection.Compared with the extraction method,this method can be easily controlled and is well suited to commercialization.The structure of the target product was confirmed by ^1HNMR,^13CNMR,IR,and MS.