巴罗沙星化学结构分析

Chemical structure analysis of balofloxacin

目的:建立药物巴罗沙星的化学结构确证方法。方法:通过使用元素分析(EA)、热分析(TA)、X射线粉末衍射(XRD)、紫外吸收光谱(UV)、红外吸收光谱(IR)、核磁共振(NMR)以及质谱(MS)等分析手段对巴罗沙星进行了结构测定。结果:证实巴罗沙星的结构为1-环丙基-6-氟-1,4-二氢-8-甲氧基-4-氧代-7-(3-甲氨基-1-哌啶基)-3-喹啉羧酸二水合物。结论:方法测定结果准确全面,可为巴罗沙星的生产和鉴定提供较为全面的参考数据。

Objective：To establish a method for the determination of the chemical structure of balofloxacin.Methods：Elemental analysis（EA）,thermal analysis（TA）,X-ray powder diffraction（XRD）,ultraviolet absorption spectrum（UV）,infrared Fourier transform spectroscopy（FT-IR）,nuclear magnetic resonance（NMR）,and mass spectrometry（MS） were adopted to analyze the chemical structure of balofloxacin.Result：The chemical structure of balofloxacin is 1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-（3-methylaminopiperidin-1-yl）-4-oxoquinoline-3-carboxylic acid dihydrate.Conclusion：The result of the method is accurate,general and can provide a comprehensive reference for production and identification of balofloxacin.