巴戟天根皮中的醌类成分的分离与鉴定

Isolation and identification of quinones constituents from root cortex of Morinda officinalis How.

目的研究巴戟天（Morinda officinalisHow.）化学成分。方法运用多种色谱学方法对巴戟天根皮体积分数70%乙醇提取物的化学成分进行分离,并根据光谱数据鉴定化合物的结构。结果从该植物中分离得到17个化合物,分别鉴定为rubiasin A（1）、rubiasin B（2）、2-羟基-1-甲氧基蒽醌（2-hydroxy-1-methoxy-anthraquinone,3）、3-羟基-1-甲氧基-2-甲基蒽醌（3-hydroxy-1-methoxy-2-methyl-anthraquinone,4）、1,3-二羟基-2-甲氧基蒽醌（1,3-dihydroxy-2-methoxy-anthraquinone,5）、2-甲基蒽醌（2-methyl-anthraquinone,6）、1,3-二羟基-2-甲基蒽醌（1,3-dihydroxy-2-methyl-anthraqui-none,7）、2-羟甲基蒽醌（2-hydroxymethyl-anthraquinone,8）、3-羟基-1,2-二甲氧基蒽醌（3-hydroxy-1,2-dimethoxy-anthraquinone,9）、1,8-二羟基-3-甲氧基-6-甲基蒽醌（1,8-dihydroxy-3-methoxy-6-methyl-anthraquinone,10）、苯乙醇-O-β-D-吡喃葡萄糖苷（2-phenylethyl-O-β-D-glucopyranoside,11）、2-丁醇-O-β-D-吡喃葡萄糖苷（sec-butyl-O-β-D-glucopyranoside,12）、3,4-二羟基苯乙醇（3,4-di-hydroxyphenylethanol,13）、3-（4-羟基-苯基）-1,2-丙二醇（3-（4-hydroxyphenyl）-1,2-propandiol,14）、阿魏酸（ferulic acid,15）、熊果酸（ursolic acid,16）、β-谷甾醇（β-sitosterol,17）。结论化合物1,2,11~14为首次从巴戟天属植物中分离得到。

Objective To study the chemical constituents from the root cortex of Morinda officinalis How..Methods Compounds were isolated through various chromatographic methods and identified by spectroscopic data.Results Seventeen compounds were obtained.Among them,ten compounds were anthraquinones,which were identified as rubiasin A（1）,rubiasin B（2）,2-hydroxy-1-methoxy-anthraquinone（3）,3-hydroxy-1-methoxy-2-methyl-anthraquinone（4）,1,3-dihydroxy-2-methoxy-anthraquinone（5）,2-methyl-anthraquinone（6）,1,3-dihydroxy-2-methyl-anthraquinone（7）,2-hydroxymethyl-anthraquinone（8）,3-hydroxy-1,2-dimethoxy-anthraquinone（9）,1,8-dihydroxy-3-methoxy-6-methyl-anthraquinone（10）;others were identified as 2-phenylethyl-O-β-D-glucopyranoside（11）,sec-butyl-O-β-D-glucopyranoside（12）,3,4-dihydroxyphenylethanol（13）,3-（4-hydroxyphenyl）-1,2-propandiol（14）,ferulic acid（15）,ursolic acid（16）and β-sitosterol（17）.Conclusions Compounds 1,2,1114 are isolated from Morinda genus for the first time.