缺血性慢性心力衰竭与贫血的相关性研究

Study on the relation between ischemic chronic heart failure and anemia

目的探讨缺血性慢性心力衰竭(CHF)与贫血的相关性。方法根据血红蛋白水平将196例患者分为贫血组54例和非贫血组1 42例,比较2组临床特征、预后、不同程度CHF患者贫血患病率及各项生化指标。结果 196例患者中,有54例出现贫血,占27.6%;轻度心力衰竭贫血患病率16.0%,明显低于重度心力衰竭(39.6%,P<0.01)。与非贫血组比较,贫血组年龄、男性比率及血肌酐明显升高,差异有统计学意义(P<0.05,P<0.01),LVEF明显降低(P<0.05);再次住院、再住院平均天数及随访期病死率明显升高(P<0.05)。与轻度心力衰竭患者比较,重度心力衰竭患者血红蛋白、红细胞平均血红蛋白浓度明显下降,差异有统计学意义(P<0.05)。结论贫血的发生与缺血性心脏病患者年龄、肾功能及心功能程度相关;贫血程度与心力衰竭程度相关;CHF合并贫血的患者预后差。

Objective To study the relation between ischemic chronic heart failure（CHF） and anemia. Methods 196 patients were divided into anemia group（54 cases） and nonanemia group（142 cases） according to hemoglobin levels. The clinical characteristics and prognosis between the two groups were compared. The incidence and hematological examination results of anemia between the patients with mild and severe CHF were compared. Results Fifty-four cases had anemia （27.6%）. There was significant difference in incidence rate of anemia between patients with mild and severe CHF（16.0% vs 39.6%, P 〈 0.01）. There were significant differences in the number of males,age,serum creatinine and the levels of LVEF between the two groups （P 〈0.05,P 0.01）. Compared with non-anemia group,the rehospitalization rate,average rehospitalization days and the mortality were higher in anemia group （P 〈 0.05）. Compared with the patients with mild CHF,the level of Hb and MCHC was significantly lower in the patients with severe CHF （P〈 0.05）. Conclusion The patients with ischemic heart disease complicated with chronic heart fail- ure often suffer from anemia. The degree of anemia is correlated with serverity of heart failure. Patients with CHF complicated with anemia have bad outcomes.