标准剂量他汀类药物治疗和控油饮食对择期介入治疗术后血脂水平的影响

Effect of standard-dose statin therapy and oil-controlling diet on blood lipid levels in patients undergoing elective PCI

目的观察择期PCI术后标准剂量他汀类药物治疗和控油饮食对血脂水平影响的效果。方法选择择期PCI的患者1 29例,按照是否实施控制油脂摄入分为控油组56例和非控油组73例,2组均给予标准剂量他汀类药物。观察术前、术后1、3和6个月血脂变化,并进行多重线性回归分析。结果与术前比较,2组术后1个月TC和LDL-C明显下降(P<0.05)。与非控油组比较,控油组患者术后1个月LDLC和TC变化值更高(P<0.05,P<0.01)。控制油脂摄入者LDL-C下降幅度大于未控油脂摄入,两组相差0.83 mmo1/L(P=0.004);女性患者较男性患者LDL-C下降明显,相差0.72 mmol/L(P=0.046)。结论择期PCI患者应用标准剂量他汀类药物治疗安全、有效,实行控油措施可进一步降低LDL-C,控油措施是血脂水平调控的重要影响因素。

Objective To observe the effect of statin therapy at standard dose and oil-controlling di et on blood lipid levels after elective pereutaneous coronary intervention（PCI）. Methods 129 patients undergoing elective PCI were given standard-dose statin therapy. According to the life-style change, 56 subjects were included in the oil-controlling group whereas the rest 73 were in the non- oil-controlling group. All patients were followed up for 6 months to observe the trend of lipid change. Results Compared with the baseline,TC and LDL C had significant reduction at 1 month point （P 〈 0.05） in both groups. Oil-controlling group had significantly more reduction of TC and I.DI.-C than non oil controlling group （P 〈0.05 ,P 〈0.01）. Multiple linear regression fur ther showed that LDL-C would decrease by 0.83 mmol/L more if the subjects controlled oil in- take （P -- 0. 004）. Female patients got more reduction than males, however, the difference was marginal （P = 0. 046）. Conclusion Standard-dose statin therapy is safe and effective for patients undergoing elective PCI and oil control will contribute to LDL C lowering.