中药促周围神经再生的研究进展

Review of study on peripheral nerve regeneration promoted by traditional Chinese medicines

周围神经损伤是外科中很常见的并发症,临床上常采用显微外科技术将断裂神经缝合,再佐以辅助疗法促进神经再生来治疗。辅助药物中常见的西药有各种神经营养因子,但其固有缺点限制了其在临床上的广泛应用。中医学将周围神经损伤归为痿证和痹证,认为其病因是经脉瘀阻、气血亏虚、筋骨不用等,故常用中药为补气、活血、通络药,单味药有丹参、黄芪、淫羊藿等;中药提取物有银杏叶、鹿茸、牛膝等。作者对这些中药及提取物的研究作一综述,以备进一步研究及开发。

Peripheral nerve impairment is a common complication in surgery,clinical researchers always do nerve sutrure using microsurgical technique and adjuvant treatment to improve peripheral nerve regeneration.Western medicine used usually adjuvant drugs,such as neurotrophic factors,are limited by their defects in clinical application.Traditional Chinese medicines（TCMs） classifies peripheral nerve impair as flaccidity Zheng and arthromyodynia,and considers that it is the result of stagnant blood block in the meridians and vessels,deficient of Qi and blood and disuse of bones and muscles.So,drugs usually have the function of invigorating vital energy,activating blood circulation and dredging collaterals.Mono-drugs include astragalus,Salvia miltiorrhiza,Astragali Radix,Epimedii Folium and so on.Extracts of TCMs have Ginkgo Folium,Cervi Cornu Pantotrichum,Achyranthis Bidentatae Radix,and so on.To be ready for further study and development,TCMs which can promote the peripheral nerve regeneration were reviewed by the literatures of the latest years.