吡格列酮治疗糖调节受损疗效观察

Clinical observation of Pioglitazone in the treatment of impaired glucose regulation

目的:评价吡格列酮治疗糖调节受损的疗效。方法:将符合糖调节受损诊断标准的患者38例,经强化生活方式干预1个月后效果不明显的,给予吡格列酮15 mg/d,疗程28周。比较治疗前后体重指数(BMI)、空腹血糖(FPG)、OGTT2h血糖(2hPG)、空腹血浆胰岛素(FINS)水平等指标。结果:加用吡格列酮治疗后,患者空腹及餐后血糖均明显降低(P<0.05),空腹INS也明显降低(P<0.01),体重指数无明显变化。结论:吡格列酮治疗糖调节受损疗效可靠,安全性好。

Objective： To evaluate the treatment of Pioglitazone in impaired glucose regulatiom.Methods： The patients,who complied with impaired glucose regulation criteria and had no obvious effection through enhancing the lifestyle interventions for one month were given Pioglitazone of 15 mg/d,with period of treatment 28 weeks.And then comparing the body mass index（BMI）,fasting plasma glucose（FPG）,OGTT2h（2hPG）,fasting glucose（fasting plasma insulin（INS） before and after the treatment.Results： Adding with Pioglitazone therapy,the fasting and postprandial glucose were significantly lower（P0.05）,fasting INS also decreased obviously（P0.01）,body mass index had no obvious change.Conclusion： Pioglitazone is reliable and safety in the treatment of impaired glucose regulatiom.