腹膜透析清除尿毒症患者血清瘦素及炎症因子效果观察

Effect observation of peritoneal dialysis on clearance of hyperleptinemia and inflammaory factor in uremic patients

目的观察持续性不卧床腹膜透析(CAPD)清除尿毒症患者血清瘦素、炎症因子的效果。方法 30例CAPD尿毒症患者为治疗组,正常体检者30例为对照组。观察治疗组透析前和透析后1、30、90 d血清5项指标[瘦素、肿瘤坏死因子(TNF)、白细胞介素6(IL-6)、白细胞介素8(IL-8)、C反应蛋白CRP)]水平变化;并观察临床5项指标[体质量指数(BMI)、血压、食欲、精神状态、贫血]的改善情况,并进行组间比较。结果治疗组血清5项指标透析前与对照组比较显著增高(P<0.01、P<0.05),透析后1、30、90 d与透析前比较显著降低(P<0.01);临床五项指标有不同程度改善(P<0.01、P<0.05)。结论 CAPD清除尿毒症患者血清瘦素及炎症因子作用明显,能改善微炎症及营养不良状态,提高患者生存质量。

Objective To observe the effect of continuous ambulatory peritoneal dialysis（CAPD） on treatment hyperleptinemia and the clearance of inflammatory factor in uraemic patients.Methods 30 uraemic patients treat with CAPD would be as treatment group,and 30 healthy ones would be as control group.Observed the change of serum leptin,TNF,IL-6,IL-8 and CRP of uraemic patients before treatment,in one day′s,30 days′ and 90 days′ treatment.And observed the body mass index（BMI）,blood pressure,appetite,mental status and the improvement of anemia at the same time.Results The serum leptin,TNF,IL-6 and IL-8 in treatment group were significantly increased than control group before treatment with CAPD（P〈0.01,P〈0.05）,while they were decreased significantly in treatment group after treatment（P〈0.01） and in one month′s treatment（P〈0.01） and in three months′ treatment（P〈0.01）.The BMI,blood pressure,appetite and mental status in treatment group were all improved in different degree（P〈0.01,P〈0.05）.Conclusion There is effective function of CAPD on clearance of serum leptin and inflammatory factors,which could improve the light inflammatory reaction,malnutrition and the quality of life for the patients.